Brief Information of the Compound and Protein
Compound Name
N-[5-[[14-(2,3-dihydroxypropylcarbamoyl)-2-oxo-6-tricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaenyl]amino]-2-fluorophenyl]thiophene-2-carboxamide
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PubChem ID
CID: 137650995
Canonical SMILES
OCC(O)CNC(=O)c1ccc2CCc3cc(Nc4ccc(F)c(NC(=O)c5cccs5)c4)ccc3C(=O)c2c1
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Compound Formula C30H26FN3O5S
Compound Structure
Protein Name
Mitogen-activated protein kinase 14
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
CMGC protein kinase group
>
CMGC protein kinase MAPK family
>
CMGC protein kinase p38 subfamily
Uniprot ID
Q16539
Gene Name
MAPK14
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000012 Sf21 Spodoptera frugiperda (Fall armyworm)  1
1
Kd = 2.4 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 1.4 nM
2 IC50 = 35.7 nM