Brief Information of the Compound and Protein
Compound Name
3-(3-bromo-4-(2,4-difluorobenzyloxy)-6-methyl-2-oxopyridin-1(2H)-yl)-N,4-dimethylbenzamide
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PubChem ID
CID: 22049997
Canonical SMILES
CNC(=O)c1ccc(C)c(c1)-n1c(C)cc(OCc2ccc(F)cc2F)c(Br)c1=O
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Compound Formula C22H19BrF2N2O3
Compound Structure
Protein Name
Mitogen-activated protein kinase 14
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
CMGC protein kinase group
>
CMGC protein kinase MAPK family
>
CMGC protein kinase p38 subfamily
Uniprot ID
Q16539
Gene Name
MAPK14
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000012 Sf21 Spodoptera frugiperda (Fall armyworm)  1
1
Kd = 2.5 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 5.8 nM
2 Ki = 2.9 nM
3 Ki = 5.8 nM