Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(-)-Pramipexole
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 PubChem ID
CID: 119570
SID: 14748917
Canonical SMILES
CCCN[C@H]1CCc2nc(N)sc2C1
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Compound Formula C10H17N3S
Compound Structure
Protein Name
 Protein Info 
D(2) dopamine receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Dopamine receptor
Uniprot ID
P14416
Gene Name
DRD2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  6
1
EC50 = 5 nM
   TI
   LI
   LO
   TS
2
IC50 > 10000 nM
   TI
   LI
   LO
   TS
3
Ki = 21 nM
   TI
   LI
   LO
   TS
4
Ki = 60 nM
   TI
   LI
   LO
   TS
5
Ki = 1900 nM
   TI
   LI
   LO
   TS
6
Ki = 6300 nM
   TI
   LI
   LO
   TS
CL000026 CHO-K1
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
Ki = 139 nM
   TI
   LI
   LO
   TS
CL000025 HEK-293T
 Cell Line Info 
Homo sapiens (Human)  7
1
EC50 = 6.457 nM
   TI
   LI
   LO
   TS
2
EC50 = 9.6 nM
   TI
   LI
   LO
   TS
3
EC50 = 27 nM
   TI
   LI
   LO
   TS
4
EC50 = 100 nM
   TI
   LI
   LO
   TS
5
Kd = 0.0149 nM
   TI
   LI
   LO
   TS
6
Ki = 25.7 nM
   TI
   LI
   LO
   TS
7
Ki = 1000 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  2
1
Ki = 4.7 nM
   TI
   LI
   LO
   TS
2
Ki = 11.1 nM
   TI
   LI
   LO
   TS
CL000035 NIH 3T3
 Cell Line Info 
Mus musculus (Mouse)  1
1
EC50 = 7.079 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 27 nM
2 Ki = 40 nM