Brief Information of the Compound and Protein
Compound Name
 Compound Info 
US10245267, Example 131
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 PubChem ID
CID: 90408826
Canonical SMILES
Cc1ncc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cnc(OC2CCOCC2)c(c1)N1CCOCC1
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Compound Formula C28H29F3N4O4
Compound Structure
Protein Name
 Protein Info 
RAF proto-oncogene serine/threonine-protein kinase
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TKL protein kinase group
>
TKL protein kinase RAF family
Uniprot ID
P04049
Gene Name
RAF1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000187 Calu-6
 Cell Line Info 
Homo sapiens (Human)  2
1
EC50 = 20 nM
   TI
   LI
   LO
   TS
2
EC50 = 100 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.119 nM