Brief Information of the Compound and Protein
Compound Name
N-[2-(2,5-difluorophenyl)-5-methylpyridin-4-yl]-1H-pyrazolo[4,3-b]pyridin-7-amine
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PubChem ID
CID: 54671061
SID: 131467522
Canonical SMILES
Cc1cnc(cc1Nc1ccnc2cn[nH]c12)-c1cc(F)ccc1F
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Compound Formula C18H13F2N5
Compound Structure
Protein Name
TGF-beta receptor type-1
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TKL protein kinase group
>
TKL protein kinase STKR family
>
TKL protein kinase STKR Type 1 subfamily
Uniprot ID
P36897
Gene Name
TGFBR1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000187 Calu-6 Homo sapiens (Human)  1
1
EC50 = 31.62 nM
   TI
   LI
   LO
   TS
CL000907 CellSensor SBE-bla HEK 293T Homo sapiens (Human)  1
1
EC50 = 7.943 nM
   TI
   LI
   LO
   TS