Brief Information of the Compound and Protein
Compound Name
4-[[5-[(3,4-dimethoxyphenyl)sulfanylmethyl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-3,5-difluorobenzonitrile
    Show/Hide
PubChem ID
CID: 137660218
Canonical SMILES
COc1ccc(SCc2cnc(SCc3c(F)cc(cc3F)C#N)n2-c2ccc(F)cc2)cc1OC
    Show/Hide
Compound Formula C26H20F3N3O2S2
Compound Structure
Protein Name
G-protein coupled bile acid receptor 1
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Lipid-like ligand receptor (family A GPCR)
>
Steroid-like ligand receptor
Uniprot ID
Q80SS6
Gene Name
GPBAR1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000851 STC 1 Homo sapiens (Human)  1
1
EC50 = 290 nM
   TI
   LI
   LO
   TS