Brief Information of the Compound and Protein
Compound Name
 Compound Info 
3-[4-(4-chlorophenyl)-7-fluoroquinolin-3-yl]sulfonylbenzonitrile
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 PubChem ID
CID: 25168930
SID: 57274751
Canonical SMILES
Fc1ccc2c(-c3ccc(Cl)cc3)c(cnc2c1)S(=O)(=O)c1cccc(c1)C#N
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Compound Formula C22H12ClFN2O2S
Compound Structure
Protein Name
 Protein Info 
Metabotropic glutamate receptor 5
Protein Classification
Membrane receptor
>
Family C G protein-coupled receptor
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Small molecule receptor (family C GPCR)
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Neurotransmitter receptor (family C GPCR)
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Metabotropic glutamate receptor
Uniprot ID
P41594
Gene Name
GRM5
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
IC50 = 133 nM
   TI
   LI
   LO
   TS
CL000666 T47D:A18
 Cell Line Info 
Homo sapiens (Human)  2
1
IC50 = 13 nM
   TI
   LI
   LO
   TS
2
Ki = 4.9 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 10.8 nM
2 Ki = 12.1 nM