Brief Information of the Compound and Protein
| Compound Name |
(Cimetidine) N-Methyl-N''''-[2-(5-methyl-1H-imidazol-4-ylmethylsulfanyl)-ethyl]-guanidine,cyanide
Show/Hide
|
PubChem ID | |||||
|
Compound Structure |
|
|||||
| Protein Name |
Histamine H2 receptor
|
Protein Classification |
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Histamine receptor
|
||||
| Uniprot ID | Gene Name | HRH2 |
|||||
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
| Cell Line ID | Cell Line Name | Cell Line Organism | |
| CL000011 | CHO | Cricetulus griseus (Chinese hamster) | 3 |
| 1 |
IC50 = 500 nM
|
TI
LI
LO
TS
|
|
|---|---|---|---|
| 2 |
IC50 = 1000 nM
|
TI
LI
LO
TS
|
|
| 3 |
Ki = 490 nM
|
TI
LI
LO
TS
|
|
Biochemical Assays
| 1 | IC50 = 140 nM | ||
|---|---|---|---|
| 2 | IC50 = 180 nM | ||
| 3 | IC50 = 270 nM | ||
| 4 | IC50 = 781 nM | ||
| 5 | Ki = 140 nM | ||
| 6 | Ki = 170 nM | ||