Brief Information of the Compound and Protein
Compound Name
 Compound Info 
N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine
    Show/Hide
 PubChem ID
CID: 3386
SID: 14874184
Canonical SMILES
CNCCC(Oc1ccc(cc1)C(F)(F)F)c1ccccc1
    Show/Hide
Compound Formula C17H18F3NO
Compound Structure
Protein Name
 Protein Info 
Sodium-dependent noradrenaline transporter
Protein Classification
Transporter
>
Electrochemical transporter
>
SLC superfamily of solute carriers
>
SLC06 neurotransmitter transporter family
Uniprot ID
P23975
Gene Name
SLC6A2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  7
1
IC50 = 1020 nM
   TI
   LI
   LO
   TS
2
IC50 = 2000 nM
   TI
   LI
   LO
   TS
3
IC50 = 4410 nM
   TI
   LI
   LO
   TS
4
IC50 = 5200 nM
   TI
   LI
   LO
   TS
5
IC50 = 6309.57 nM
   TI
   LI
   LO
   TS
6
Ki = 1394 nM
   TI
   LI
   LO
   TS
7
Ki = 1560 nM
   TI
   LI
   LO
   TS
CL000031 MDCK
 Cell Line Info 
Canis lupus familiaris (Dog)  2
1
IC50 = 563 nM
   TI
   LI
   LO
   TS
2
IC50 = 2535 nM
   TI
   LI
   LO
   TS
CL000882 MDCK-Net6
 Cell Line Info 
Canis lupus familiaris (Dog)  1
1
IC50 = 563 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Kd = 240 nM
2 Ki = 440 nM
3 Ki = 2000 nM