Brief Information of the Compound and Protein
Compound Name
N-(benzo[d][1,3]dioxol-5-ylmethyl)-4-(6,7-dimethoxy-9H-pyrimido[4,5-b]indol-4-yl)piperazine-1-carbothioamide
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PubChem ID
CID: 11237489
SID: 16321457
Canonical SMILES
COc1cc2[nH]c3ncnc(N4CCN(C(=S)NCc5ccc6c(c5)OCO6)CC4)c3c2cc1OC
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Compound Formula C25H26N6O4S
Compound Structure
Protein Name
Platelet-derived growth factor receptor alpha
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase PDGFR family
Uniprot ID
P16234
Gene Name
PDGFRA
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000207 MIA PaCa-2 Homo sapiens (Human)  1
1
IC50 = 15500 nM
   TI
   LI
   LO
   TS
CL000206 PANC-1 Homo sapiens (Human)  1
1
IC50 = 16000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 EC50 = 428.75 nM