Brief Information of the Compound and Protein
Compound Name
Amuvatinib
    Show/Hide
PubChem ID
CID: 11282283
SID: 16369229
Canonical SMILES
S=C(NCc1ccc2OCOc2c1)N1CCN(CC1)c1ncnc2c3ccccc3oc12
    Show/Hide
Compound Formula C23H21N5O3S
Compound Structure
Protein Name
Platelet-derived growth factor receptor alpha
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase PDGFR family
Uniprot ID
P16234
Gene Name
PDGFRA
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000207 MIA PaCa-2 Homo sapiens (Human)  1
1
IC50 = 2100 nM
   TI
   LI
   LO
   TS
CL000206 PANC-1 Homo sapiens (Human)  1
1
IC50 = 3000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 EC50 = 27163 nM