Brief Information of the Compound and Protein
Compound Name
N-(2,6-dichloro-3,5-dimethoxyphenyl)-N-(3-(4-methoxypyrimidin-2-yl)prop-2-ynyl)-3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-amine
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PubChem ID
CID: 88888597
Canonical SMILES
COc1ccnc(C#CCN(c2ccc3ncc(-c4cnn(C)c4)nc3c2)c2c(Cl)c(OC)cc(OC)c2Cl)n1
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Compound Formula C28H23Cl2N7O3
Compound Structure
Protein Name
Vascular endothelial growth factor receptor 2
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase VEGFR family
Uniprot ID
P35968
Gene Name
KDR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000077 Ba/F3 Mus musculus (Mouse)  2
1
IC50 = 2187.76 nM
   TI
   LI
   LO
   TS
2
IC50 = 9120.11 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 138.04 nM