Brief Information of the Compound and Protein
Compound Name
 Compound Info 
1-(3-chlorophenyl)piperazine
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 PubChem ID
CID: 1355
SID: 15487730
Canonical SMILES
Clc1cccc(c1)N1CCNCC1
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Compound Formula C10H13ClN2
Compound Structure
Protein Name
 Protein Info 
5-hydroxytryptamine receptor 2A
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Serotonin receptor
Uniprot ID
P28223
Gene Name
HTR2A
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
EC50 = 75 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  5
1
EC50 = 7.2 nM
   TI
   LI
   LO
   TS
2
EC50 = 63.1 nM
   TI
   LI
   LO
   TS
3
EC50 = 251.19 nM
   TI
   LI
   LO
   TS
4
EC50 = 290 nM
   TI
   LI
   LO
   TS
5
Ki = 25.12 nM
   TI
   LI
   LO
   TS
CL000065 HEK293-EBNA
 Cell Line Info 
Homo sapiens (Human)  2
1
EC50 = 290 nM
   TI
   LI
   LO
   TS
2
Ki = 48 nM
   TI
   LI
   LO
   TS
CL000035 NIH 3T3
 Cell Line Info 
Mus musculus (Mouse)  1
1
EC50 = 167 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 32 nM
2 Ki = 54 nM
3 Ki = 273 nM