Brief Information of the Compound and Protein
Compound Name
4-(5-methylsulfonyl-6,7-dihydro-4H-furo[3,2-c]pyridin-2-yl)-N-[4-(2-pyrrolidin-1-ylethoxy)phenyl]pyrimidin-2-amine
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PubChem ID
CID: 72201957
Canonical SMILES
CS(=O)(=O)N1CCc2oc(cc2C1)-c1ccnc(Nc2ccc(OCCN3CCCC3)cc2)n1
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Compound Formula C24H29N5O4S
Compound Structure
Protein Name
Tyrosine-protein kinase JAK2
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase JakB family
Uniprot ID
O60674
Gene Name
JAK2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000082 HEL Homo sapiens (Human)  1
1
IC50 = 1258 nM
   TI
   LI
   LO
   TS
CL000128 TF-1 Homo sapiens (Human)  1
1
IC50 = 4311 nM
   TI
   LI
   LO
   TS