Brief Information of the Compound and Protein
Compound Name
3-[2-[2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]-6,7-dihydro-4H-furo[3,2-c]pyridin-5-yl]-3-oxopropanenitrile
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PubChem ID
CID: 72202400
Canonical SMILES
CN1CCN(CC1)c1ccc(Nc2nccc(n2)-c2cc3CN(CCc3o2)C(=O)CC#N)cc1
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Compound Formula C25H27N7O2
Compound Structure
Protein Name
Tyrosine-protein kinase JAK2
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase JakB family
Uniprot ID
O60674
Gene Name
JAK2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000082 HEL Homo sapiens (Human)  1
1
IC50 = 7443 nM
   TI
   LI
   LO
   TS
CL000128 TF-1 Homo sapiens (Human)  1
1
IC50 = 2338 nM
   TI
   LI
   LO
   TS