Brief Information of the Compound and Protein
Compound Name
6-[2-chloro-4-(1,3-thiazol-5-yl)phenyl]-8-ethyl-2-[4-(4-methylpiperazin-1-yl)anilino]pyrido[2,3-d]pyrimidin-7-one
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PubChem ID
CID: 70934541
SID: 163453929
Canonical SMILES
CCn1c2nc(Nc3ccc(cc3)N3CCN(C)CC3)ncc2cc(-c2ccc(cc2Cl)-c2cncs2)c1=O
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Compound Formula C29H28ClN7OS
Compound Structure
Protein Name
Serine/threonine-protein kinase PAK 1
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
STE protein kinase group
>
STE protein kinase STE20 family
>
STE protein kinase PAKA subfamily
Uniprot ID
Q13153
Gene Name
PAK1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000243 MCF-10A Homo sapiens (Human)  1
1
IC50 = 88 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 2.8 nM
2 IC50 = 7.7 nM
3 IC50 <= 10 nM
4 IC50 = 14 nM
5 IC50 = 23 nM