Brief Information of the Compound and Protein
Compound Name
 Compound Info 
AMG-837
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 PubChem ID
CID: 46854655
SID: 123047982
Canonical SMILES
CC#C[C@@H](CC(O)=O)c1ccc(OCc2cccc(c2)-c2ccc(cc2)C(F)(F)F)cc1
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Compound Formula C26H21F3O3
Compound Structure
Protein Name
 Protein Info 
Free fatty acid receptor 1
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Lipid-like ligand receptor (family A GPCR)
>
Free fatty acid receptor
Uniprot ID
O14842
Gene Name
FFAR1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000094 1321N1
 Cell Line Info 
Homo sapiens (Human)  2
1
EC50 = 100 nM
   TI
   LI
   LO
   TS
2
EC50 = 169.82 nM
   TI
   LI
   LO
   TS
CL000398 A-9
 Cell Line Info 
Mus musculus (Mouse)  1
1
EC50 = 41 nM
   TI
   LI
   LO
   TS
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  5
1
EC50 = 13 nM
   TI
   LI
   LO
   TS
2
EC50 = 60 nM
   TI
   LI
   LO
   TS
3
EC50 = 80 nM
   TI
   LI
   LO
   TS
4
EC50 = 104 nM
   TI
   LI
   LO
   TS
5
EC50 = 8800 nM
   TI
   LI
   LO
   TS
CL000460 Flp-In-T-REx-293
 Cell Line Info 
Homo sapiens (Human)  1
1
Ki = 41.69 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  5
1
EC50 = 1.3 nM
   TI
   LI
   LO
   TS
2
EC50 = 2.2 nM
   TI
   LI
   LO
   TS
3
EC50 = 11 nM
   TI
   LI
   LO
   TS
4
EC50 = 15 nM
   TI
   LI
   LO
   TS
5
EC50 = 154.88 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 EC50 = 13 nM
2 EC50 = 23 nM