Brief Information of the Compound and Protein
Compound Name
N-[3-[2-[3-amino-6-[1-[1-(2-hydroxyacetyl)piperidin-4-yl]pyrazol-4-yl]pyrazin-2-yl]benzimidazol-1-yl]phenyl]prop-2-enamide
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PubChem ID
CID: 127050558
Canonical SMILES
Nc1ncc(nc1-c1nc2ccccc2n1-c1cccc(NC(=O)C=C)c1)-c1cnn(c1)C1CCN(CC1)C(=O)CO
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Compound Formula C30H29N9O3
Compound Structure
Protein Name
Epidermal growth factor receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase EGFR family
Uniprot ID
P00533
Gene Name
EGFR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000323 LoVo Homo sapiens (Human)  1
1
EC50 = 3000 nM
   TI
   LI
   LO
   TS
CL000157 NCI-H1975 Homo sapiens (Human)  1
1
EC50 = 24 nM
   TI
   LI
   LO
   TS