Brief Information of the Compound and Protein
Compound Name
6-[[(6S)-6-methyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl]oxy]-N-[5-[1-(trifluoromethyl)cyclopropyl]-1,2-oxazol-3-yl]indole-1-carboxamide
    Show/Hide
PubChem ID
CID: 127045061
Canonical SMILES
C[C@H]1Cc2c(CN1)ncnc2Oc1ccc2ccn(C(=O)Nc3cc(on3)C3(CC3)C(F)(F)F)c2c1
    Show/Hide
Compound Formula C24H21F3N6O3
Compound Structure
Protein Name
Vascular endothelial growth factor receptor 2
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase VEGFR family
Uniprot ID
P35968
Gene Name
KDR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000077 Ba/F3 Mus musculus (Mouse)  1
1
IC50 = 134 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 160 nM