Brief Information of the Compound and Protein
Compound Name
N-methyl-3-[(1-methylindazol-5-yl)methyl]-2H-indazole-5-carboxamide
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PubChem ID
CID: 118960212
Canonical SMILES
CNC(=O)c1ccc2[nH]nc(Cc3ccc4n(C)ncc4c3)c2c1
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Compound Formula C18H17N5O
Compound Structure
Protein Name
Cyclin-dependent kinase 8
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
CMGC protein kinase group
>
CMGC protein kinase CDK family
>
CMGC protein kinase CDK8 subfamily
Uniprot ID
P49336
Gene Name
CDK8
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 65 nM
   TI
   LI
   LO
   TS
CL000103 LS174T Homo sapiens (Human)  2
1
IC50 = 340 nM
   TI
   LI
   LO
   TS
2
IC50 = 710 nM
   TI
   LI
   LO
   TS
CL000104 SW620 Homo sapiens (Human)  1
1
IC50 = 49 nM
   TI
   LI
   LO
   TS