Brief Information of the Compound and Protein
Compound Name
FTC
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PubChem ID
CID: 403923
SID: 56310587
Canonical SMILES
COc1ccc2c3C[C@@H]4N([C@@H](C=C(C)C)c3[nH]c2c1)C(=O)[C@@H]1CCCN1C4=O
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Compound Formula C22H25N3O3
Compound Structure
Protein Name
Broad substrate specificity ATP-binding cassette transporter ABCG2
Protein Classification
Transporter
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Primary active transporter
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ATP-binding cassette
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ABCG subfamily
Uniprot ID
Q9UNQ0
Gene Name
ABCG2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000836 H460/MX20 Homo sapiens (Human)  3
1
IC50 = 321 nM
   TI
   LI
   LO
   TS
2
IC50 = 451 nM
   TI
   LI
   LO
   TS
3
IC50 = 612 nM
   TI
   LI
   LO
   TS
CL000781 MCF7/Topo Homo sapiens (Human)  4
1
IC50 = 730 nM
   TI
   LI
   LO
   TS
2
IC50 = 731 nM
   TI
   LI
   LO
   TS
3
IC50 = 960 nM
   TI
   LI
   LO
   TS
4
IC50 > 11000 nM
   TI
   LI
   LO
   TS
CL000145 NCI-H460 Homo sapiens (Human)  1
1
IC50 = 800 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 EC50 = 1000 nM