Brief Information of the Compound and Protein
Compound Name
 Compound Info 
1-(4-chlorophenyl)-3-[3-(6-pyrrolidin-1-ylpyridin-2-yl)phenyl]urea
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 PubChem ID
CID: 11560249
SID: 16662513
Canonical SMILES
Clc1ccc(NC(=O)Nc2cccc(c2)-c2cccc(n2)N2CCCC2)cc1
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Compound Formula C22H21ClN4O
Compound Structure
Protein Name
 Protein Info 
Cannabinoid receptor 1
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Lipid-like ligand receptor (family A GPCR)
>
Cannabinoid receptor
Uniprot ID
P21554
Gene Name
CNR1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
IC50 = 33 nM
   TI
   LI
   LO
   TS
CL000026 CHO-K1
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  3
1
EC50 = 3.84 nM
   TI
   LI
   LO
   TS
2
EC50 = 70.8 nM
   TI
   LI
   LO
   TS
3
EC50 = 270 nM
   TI
   LI
   LO
   TS
CL000076 CHO/Galpha16
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  3
1
IC50 = 31.62 nM
   TI
   LI
   LO
   TS
2
IC50 = 32.5 nM
   TI
   LI
   LO
   TS
3
IC50 = 33 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  7
1
EC50 = 167 nM
   TI
   LI
   LO
   TS
2
IC50 = 1.47 nM
   TI
   LI
   LO
   TS
3
IC50 = 50 nM
   TI
   LI
   LO
   TS
4
IC50 = 230 nM
   TI
   LI
   LO
   TS
5
IC50 = 398.11 nM
   TI
   LI
   LO
   TS
6
IC50 = 455 nM
   TI
   LI
   LO
   TS
7
IC50 = 2620 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 33 nM
2 IC50 = 102 nM