Brief Information of the Compound and Protein
Compound Name
 Compound Info 
1-propan-2-yl-3-(5-pyridin-2-yl-1,2-oxazol-3-yl)pyrazolo[3,4-d]pyrimidin-4-amine
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 PubChem ID
CID: 126592040
Canonical SMILES
CC(C)n1nc(-c2cc(on2)-c2ccccn2)c2c(N)ncnc12
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Compound Formula C16H15N7O
Compound Structure
Protein Name
 Protein Info 
Proto-oncogene tyrosine-protein kinase receptor Ret
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase Ret family
Uniprot ID
P07949
Gene Name
RET
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000077 Ba/F3
 Cell Line Info 
Mus musculus (Mouse)  2
1
GI50 = 700 nM
   TI
   LI
   LO
   TS
2
GI50 = 1110 nM
   TI
   LI
   LO
   TS
CL000425 TT
 Cell Line Info 
Homo sapiens (Human)  1
1
GI50 = 9260 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 910 nM
2 IC50 = 5880 nM