Brief Information of the Compound and Protein
Compound Name
N-(5-tert-butyl-1,2-oxazol-3-yl)-5-[[(5S)-5-methyl-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-yl]oxy]indole-1-carboxamide
    Show/Hide
PubChem ID
CID: 127041601
Canonical SMILES
C[C@@H]1NCc2ncnc(Oc3ccc4n(ccc4c3)C(=O)Nc3cc(on3)C(C)(C)C)c12
    Show/Hide
Compound Formula C23H24N6O3
Compound Structure
Protein Name
Vascular endothelial growth factor receptor 2
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase VEGFR family
Uniprot ID
P35968
Gene Name
KDR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000077 Ba/F3 Mus musculus (Mouse)  1
1
IC50 = 8 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 22 nM