Brief Information of the Compound and Protein
Compound Name
 Compound Info 
US10053462, 30
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 PubChem ID
CID: 90414879
Canonical SMILES
FC(F)(F)c1cccc(C(=O)N2[C@@H]3CCC[C@H]2c2nnc(-c4ccc(Cl)cn4)n2C3)c1Cl
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Compound Formula C21H16Cl2F3N5O
Compound Structure
Protein Name
 Protein Info 
P2X purinoceptor 7
Protein Classification
Ion channel
>
Ligand-gated ion channel
>
P2X receptor
Uniprot ID
Q99572
Gene Name
P2RX7
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000094 1321N1
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 118.3 nM
   TI
   LI
   LO
   TS
CL000881 P2X7-1321N1
 Cell Line Info 
Homo sapiens (Human)  1
1
Ki = 35.5 nM
   TI
   LI
   LO
   TS