Brief Information of the Compound and Protein
Compound Name
US10047092, 2
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PubChem ID
CID: 86279279
Canonical SMILES
Clc1cccc(CN2CCn3c(nnc3-c3cnccn3)C2=O)c1Cl
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Compound Formula C16H12Cl2N6O
Compound Structure
Protein Name
P2X purinoceptor 7
Protein Classification
Ion channel
>
Ligand-gated ion channel
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P2X receptor
Uniprot ID
Q99572
Gene Name
P2RX7
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000094 1321N1 Homo sapiens (Human)  1
1
IC50 = 438.5 nM
   TI
   LI
   LO
   TS
CL000881 P2X7-1321N1 Homo sapiens (Human)  1
1
Ki = 28.8 nM
   TI
   LI
   LO
   TS