Brief Information of the Compound and Protein
Compound Name
 Compound Info 
AAT-007
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 PubChem ID
CID: 11677589
SID: 16781607
Canonical SMILES
CCc1nc2c(C)nc(C)cc2n1-c1ccc(CCNC(=O)NS(=O)(=O)c2ccc(C)cc2)cc1
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Compound Formula C26H29N5O3S
Compound Structure
Protein Name
 Protein Info 
Prostaglandin E2 receptor EP4 subtype
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
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Lipid-like ligand receptor (family A GPCR)
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Prostanoid receptor
Uniprot ID
P35408
Gene Name
PTGER4
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  5
1
IC50 = 11.7 nM
   TI
   LI
   LO
   TS
2
IC50 = 689 nM
   TI
   LI
   LO
   TS
3
Kd = 4.786 nM
   TI
   LI
   LO
   TS
4
Ki = 13 nM
   TI
   LI
   LO
   TS
5
Ki = 449 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 1614 nM
2 Ki = 448 nM