Brief Information of the Compound and Protein
Compound Name
 Compound Info 
N-(5-ethyl-3-isoxazolyl)-N'-[4-(2-[6-(4-ethylpiperazino)-2-methyl-4-pyrimidinyl]amino-1,3-thiazol-5-yl)phenyl]urea
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 PubChem ID
CID: 88876355
Canonical SMILES
CCc1cc(NC(=O)Nc2ccc(-c3cnc(Nc4cc(N5CCN(CC)CC5)nc(C)n4)s3)cc2)no1
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Compound Formula C26H31N9O2S
Compound Structure
Protein Name
 Protein Info 
Receptor-type tyrosine-protein kinase FLT3
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase PDGFR family
Uniprot ID
P36888
Gene Name
FLT3
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000605 32D
 Cell Line Info 
Mus musculus (Mouse)  4
1
GI50 = 4 nM
   TI
   LI
   LO
   TS
2
GI50 = 6 nM
   TI
   LI
   LO
   TS
3
GI50 = 38 nM
   TI
   LI
   LO
   TS
4
GI50 = 70 nM
   TI
   LI
   LO
   TS
CL000025 HEK-293T
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 10 nM
   TI
   LI
   LO
   TS
CL000071 MOLM-13
 Cell Line Info 
Homo sapiens (Human)  1
1
GI50 = 2 nM
   TI
   LI
   LO
   TS
CL000091 MV4-11
 Cell Line Info 
Homo sapiens (Human)  1
1
GI50 = 1 nM
   TI
   LI
   LO
   TS
CL000120 RS4;11
 Cell Line Info 
Homo sapiens (Human)  1
1
GI50 = 110 nM
   TI
   LI
   LO
   TS
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  1
1
IC50 = 38 nM
   TI
   LI
   LO
   TS