Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

hydron;pyridine-3-carboxylate

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PubChem ID

CID: 117629482

SID: 87550957

Canonical SMILES	OC(=O)c1cccnc1 Show/Hide
Compound Formula	C6H5NO2

Compound Structure

Protein Name

Protein Info

Hydroxycarboxylic acid receptor 2

Protein Classification

Membrane receptor

Family A G protein-coupled receptor

Small molecule receptor (family A GPCR)

Carboxylic acid receptor

Hydroxycarboxylic acid receptor

Uniprot ID

Q8TDS4

Gene Name

HCAR2

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	8
1	EC50 = 27 nM	TI LI LO TS
2	EC50 = 51 nM	TI LI LO TS
3	EC50 = 99 nM	TI LI LO TS
4	EC50 = 100 nM	TI LI LO TS
5	EC50 = 120 nM	TI LI LO TS
6	EC50 = 1000 nM	TI LI LO TS
7	IC50 = 140 nM	TI LI LO TS
8	IC50 = 150 nM	TI LI LO TS
CL000026	CHO-K1 Cell Line Info	Cricetulus griseus (Chinese hamster)	11
1	EC50 = 26.92 nM	TI LI LO TS
2	EC50 = 47 nM	TI LI LO TS
3	EC50 = 527 nM	TI LI LO TS
4	EC50 = 580 nM	TI LI LO TS
5	EC50 = 1000 nM	TI LI LO TS
6	EC50 = 1400 nM	TI LI LO TS
7	IC50 = 130 nM	TI LI LO TS
8	IC50 = 140 nM	TI LI LO TS
9	IC50 = 67300 nM	TI LI LO TS
10	Ki = 82 nM	TI LI LO TS
11	Ki = 104 nM	TI LI LO TS
CL000025	HEK-293T Cell Line Info	Homo sapiens (Human)	2
1	EC50 = 5000 nM	TI LI LO TS
2	IC50 = 249 nM	TI LI LO TS
CL000065	HEK293-EBNA Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 500 nM	TI LI LO TS

Biochemical Assays