Brief Information of the Compound and Protein
Compound Name
N-(2-((5-chloro-2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)amino)phenyl)acrylamide
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PubChem ID
CID: 122181364
Canonical SMILES
C=CC(=O)Nc1ccccc1Nc1nc(Nc2ccnn2C)ncc1Cl
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Compound Formula C17H16ClN7O
Compound Structure
Protein Name
Mitogen-activated protein kinase 1
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
CMGC protein kinase group
>
CMGC protein kinase MAPK family
>
CMGC protein kinase ERK subfamily
Uniprot ID
P28482
Gene Name
MAPK1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000045 A-375 Homo sapiens (Human)  1
1
IC50 = 48 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 9.9 nM
2 IC50 = 13 nM