Brief Information of the Compound and Protein
Compound Name
N-(4-((5-chloro-2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)amino)pyridin-3-yl)acrylamide
    Show/Hide
PubChem ID
CID: 122181362
Canonical SMILES
C=CC(=O)Nc1cnccc1Nc1nc(NC2CCOCC2)ncc1Cl
    Show/Hide
Compound Formula C17H19ClN6O2
Compound Structure
Protein Name
Mitogen-activated protein kinase 1
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
CMGC protein kinase group
>
CMGC protein kinase MAPK family
>
CMGC protein kinase ERK subfamily
Uniprot ID
P28482
Gene Name
MAPK1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000045 A-375 Homo sapiens (Human)  1
1
IC50 = 6.7 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 3 nM
2 IC50 = 3.1 nM