Brief Information of the Compound and Protein
Compound Name
 Compound Info 
N-[2-[[5-chloro-2-[[4-(dimethylamino)cyclohexyl]amino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide
    Show/Hide
Canonical SMILES
CN(C)[C@H]1CC[C@@H](CC1)Nc1ncc(Cl)c(Nc2ccccc2NC(=O)C=C)n1
    Show/Hide
Compound Formula C21H27ClN6O
Compound Structure
Protein Name
 Protein Info 
Mitogen-activated protein kinase 1
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
CMGC protein kinase group
>
CMGC protein kinase MAPK family
>
CMGC protein kinase ERK subfamily
Uniprot ID
P28482
Gene Name
MAPK1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000045 A-375
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 72 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 85 nM
2 IC50 = 90 nM