Brief Information of the Compound and Protein
Compound Name
N-[2-[[2-(oxan-4-ylamino)-5-(trifluoromethyl)pyrimidin-4-yl]amino]phenyl]prop-2-enamide
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PubChem ID
CID: 91809196
Canonical SMILES
FC(F)(F)c1cnc(NC2CCOCC2)nc1Nc1ccccc1NC(=O)C=C
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Compound Formula C19H20F3N5O2
Compound Structure
Protein Name
Mitogen-activated protein kinase 1
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
CMGC protein kinase group
>
CMGC protein kinase MAPK family
>
CMGC protein kinase ERK subfamily
Uniprot ID
P28482
Gene Name
MAPK1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000045 A-375 Homo sapiens (Human)  1
1
IC50 = 22 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 6.9 nM
2 IC50 = 8.5 nM