Brief Information of the Compound and Protein
Compound Name
N-[2-[[4-[2-(3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]phenyl]quinoline-3-carboxamide
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PubChem ID
CID: 15950351
SID: 22421776
Canonical SMILES
O=C(Nc1ccccc1C(=O)Nc1ccc(CCN2CCc3ccccc3C2)cc1)c1cnc2ccccc2c1
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Compound Formula C34H30N4O2
Compound Structure
Protein Name
Broad substrate specificity ATP-binding cassette transporter ABCG2
Protein Classification
Transporter
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Primary active transporter
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ATP-binding cassette
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ABCG subfamily
Uniprot ID
Q9UNQ0
Gene Name
ABCG2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000083 MCF-7 Homo sapiens (Human)  3
1
IC50 = 676.08 nM
   TI
   LI
   LO
   TS
2
IC50 = 831.76 nM
   TI
   LI
   LO
   TS
3
IC50 = 1000 nM
   TI
   LI
   LO
   TS
CL000036 MDCK-II Canis lupus familiaris (Dog)  3
1
IC50 = 704 nM
   TI
   LI
   LO
   TS
2
IC50 = 721 nM
   TI
   LI
   LO
   TS
3
IC50 = 741 nM
   TI
   LI
   LO
   TS