Brief Information of the Compound and Protein
Compound Name
 Compound Info 
N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]-4-(1-methylpyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-amine
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 PubChem ID
CID: 72716071
Canonical SMILES
COc1cc(ccc1Nc1nccc(n1)-c1cn(C)c2cnccc12)N1CCN(C)CC1
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Compound Formula C24H27N7O
Compound Structure
Protein Name
 Protein Info 
Dual specificity tyrosine-phosphorylation-regulated kinase 1B
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
CMGC protein kinase group
>
CMGC protein kinase DYRK family
>
CMGC protein kinase Dyrk1 subfamily
Uniprot ID
Q9Y463
Gene Name
DYRK1B
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000109 COS-1
 Cell Line Info 
Chlorocebus aethiops (Green monkey)  1
1
IC50 = 42 nM
   TI
   LI
   LO
   TS
CL000025 HEK-293T
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 81 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 3 nM
2 Ki = 11.2 nM