Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(3R,5S)-5-(2,6-dimethoxyphenyl)-3-(methylamino)-1-[[4-(trifluoromethoxy)phenyl]methyl]pyrrolidin-2-one
    Show/Hide
 PubChem ID
CID: 118731954
Canonical SMILES
CN[C@@H]1C[C@H](N(Cc2ccc(OC(F)(F)F)cc2)C1=O)c1c(OC)cccc1OC
    Show/Hide
Compound Formula C21H23F3N2O4
Compound Structure
Protein Name
 Protein Info 
Orexin/Hypocretin receptor type 1
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Short peptide receptor (family A GPCR)
>
Orexin receptor
Uniprot ID
O43613
Gene Name
HCRTR1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
IC50 = 2400 nM
   TI
   LI
   LO
   TS