Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(3S,5S)-5-(2,6-dimethoxyphenyl)-3-ethoxy-1-[[4-(trifluoromethoxy)phenyl]methyl]pyrrolidin-2-one
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 PubChem ID
CID: 118731950
Canonical SMILES
CCO[C@H]1C[C@H](N(Cc2ccc(OC(F)(F)F)cc2)C1=O)c1c(OC)cccc1OC
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Compound Formula C22H24F3NO5
Compound Structure
Protein Name
 Protein Info 
Orexin/Hypocretin receptor type 1
Protein Classification
Membrane receptor
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Family A G protein-coupled receptor
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Peptide receptor (family A GPCR)
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Short peptide receptor (family A GPCR)
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Orexin receptor
Uniprot ID
O43613
Gene Name
HCRTR1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
IC50 = 3960 nM
   TI
   LI
   LO
   TS