Brief Information of the Compound and Protein
Compound Name
 Compound Info 
FORETINIB
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 PubChem ID
CID: 42642645
SID: 81082087
Canonical SMILES
COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1
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Compound Formula C34H34F2N4O6
Compound Structure
Protein Name
 Protein Info 
Proto-oncogene tyrosine-protein kinase ROS
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase Sev family
Uniprot ID
P08922
Gene Name
ROS1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000077 Ba/F3
 Cell Line Info 
Mus musculus (Mouse)  1
1
IC50 = 10 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Kd = 14 nM
2 Ki = 8.2 nM
3 Ki = 16 nM
4 Ki = 20 nM