Brief Information of the Compound and Protein
Compound Name
 Compound Info 
5-(azetidin-1-yl)-N-[(5,6-dimethoxypyridin-2-yl)methyl]-2-(5-methylpyridin-3-yl)pyridine-4-carboxamide
    Show/Hide
 PubChem ID
CID: 46191727
SID: 96045373
Canonical SMILES
COc1ccc(CNC(=O)c2cc(ncc2N2CCC2)-c2cncc(C)c2)nc1OC
    Show/Hide
Compound Formula C23H25N5O3
Compound Structure
Protein Name
 Protein Info 
Orexin/Hypocretin receptor type 1
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Short peptide receptor (family A GPCR)
>
Orexin receptor
Uniprot ID
O43613
Gene Name
HCRTR1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  2
1
IC50 = 10000 nM
   TI
   LI
   LO
   TS
2
Ki = 18000 nM
   TI
   LI
   LO
   TS