Brief Information of the Compound and Protein
Compound Name
 Compound Info 
ethyl 4-(13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidine-1-carboxylate
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 PubChem ID
CID: 3957
SID: 12013131
Canonical SMILES
CCOC(=O)N1CCC(CC1)=C1c2ccc(Cl)cc2CCc2cccnc12
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Compound Formula C22H23ClN2O2
Compound Structure
Protein Name
 Protein Info 
Histamine H1 receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Histamine receptor
Uniprot ID
P35367
Gene Name
HRH1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  2
1
Kd = 190 nM
   TI
   LI
   LO
   TS
2
Ki = 37 nM
   TI
   LI
   LO
   TS
CL000026 CHO-K1
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
Ki = 414 nM
   TI
   LI
   LO
   TS
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  1
1
Ki = 311 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 290 nM