Brief Information of the Compound and Protein
Compound Name
 Compound Info 
6-cyclopropyl-8-fluoro-2-[2-(hydroxymethyl)-3-[1-methyl-5-[[5-(4-methylpiperazin-1-yl)pyridin-2-yl]amino]-6-oxopyridin-3-yl]phenyl]isoquinolin-1-one
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 PubChem ID
CID: 46908026
SID: 99368811
Canonical SMILES
CN1CCN(CC1)c1ccc(Nc2cc(cn(C)c2=O)-c2cccc(c2CO)-n2ccc3cc(cc(F)c3c2=O)C2CC2)nc1
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Compound Formula C35H35FN6O3
Compound Structure
Protein Name
 Protein Info 
Tyrosine-protein kinase BTK
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase Tec family
Uniprot ID
Q06187
Gene Name
BTK
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000003 Ramos
 Cell Line Info 
Homo sapiens (Human)  2
1
IC50 = 27 nM
   TI
   LI
   LO
   TS
2
IC50 = 27.3 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.3 nM
2 IC50 = 0.9 nM
3 IC50 = 2.25 nM
4 IC50 = 4 nM
5 IC50 = 7 nM
6 IC50 = 13 nM
7 IC50 = 13.2 nM