Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolidin-1-ylsulfonyl)phenol
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 PubChem ID
CID: 6604889
SID: 14852068
Canonical SMILES
CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(O)c2)CC1
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Compound Formula C18H28N2O3S
Compound Structure
Protein Name
 Protein Info 
5-hydroxytryptamine receptor 7
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Serotonin receptor
Uniprot ID
P34969
Gene Name
HTR7
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  5
1
IC50 = 0.93 nM
   TI
   LI
   LO
   TS
2
Ki = 0.34 nM
   TI
   LI
   LO
   TS
3
Ki = 0.71 nM
   TI
   LI
   LO
   TS
4
Ki = 1.26 nM
   TI
   LI
   LO
   TS
5
Ki = 1.9 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  4
1
Ki = 0.34 nM
   TI
   LI
   LO
   TS
2
Ki = 1 nM
   TI
   LI
   LO
   TS
3
Ki = 1.2 nM
   TI
   LI
   LO
   TS
4
Ki = 1.259 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Kd = 9.7 nM
2 Ki = 1 nM
3 Ki = 1.25 nM
4 Ki = 1.26 nM
5 Ki = 1.3 nM