Brief Information of the Compound and Protein
Compound Name
 Compound Info 
11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
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 PubChem ID
CID: 4848
SID: 14852009
Canonical SMILES
CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
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Compound Formula C19H21N5O2
Compound Structure
Protein Name
 Protein Info 
Muscarinic acetylcholine receptor M4
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Acetylcholine receptor
Uniprot ID
P08173
Gene Name
CHRM4
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
IC50 = 246.8 nM
   TI
   LI
   LO
   TS
CL000026 CHO-K1
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
Ki = 13.8 nM
   TI
   LI
   LO
   TS
CL000025 HEK-293T
 Cell Line Info 
Homo sapiens (Human)  2
1
IC50 = 1.148 nM
   TI
   LI
   LO
   TS
2
IC50 = 1047.13 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 105 nM