Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

5-(4-Hexyloxy-[1,2,5]thiadiazol-3-yl)-1-methyl-1,2,3,6-tetrahydro-pyridine; oxalic acid

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PubChem ID

CID: 60809

SID: 15222271

Canonical SMILES	CCCCCCOc1nsnc1C1=CCCN(C)C1 Show/Hide
Compound Formula	C14H23N3OS

Compound Structure

Protein Name

Protein Info

Muscarinic acetylcholine receptor M1

Protein Classification

Membrane receptor

Family A G protein-coupled receptor

Small molecule receptor (family A GPCR)

Monoamine receptor

Acetylcholine receptor

Uniprot ID

P11229

Gene Name

CHRM1

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000398	A-9 Cell Line Info	Mus musculus (Mouse)	8
1	EC50 = 10 nM	TI LI LO TS
2	EC50 = 57 nM	TI LI LO TS
3	EC50 = 158.49 nM	TI LI LO TS
4	EC50 = 200 nM	TI LI LO TS
5	EC50 = 316.23 nM	TI LI LO TS
6	Ki = 82 nM	TI LI LO TS
7	Ki = 158.49 nM	TI LI LO TS
8	Ki = 3981.07 nM	TI LI LO TS
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	9
1	EC50 = 67.3 nM	TI LI LO TS
2	IC50 = 18.2 nM	TI LI LO TS
3	IC50 = 28.84 nM	TI LI LO TS
4	IC50 = 81.28 nM	TI LI LO TS
5	IC50 = 954.99 nM	TI LI LO TS
6	IC50 = 2398.83 nM	TI LI LO TS
7	IC50 = 4897.79 nM	TI LI LO TS
8	Ki = 7.943 nM	TI LI LO TS
9	Ki = 42 nM	TI LI LO TS
CL000026	CHO-K1 Cell Line Info	Cricetulus griseus (Chinese hamster)	1
1	EC50 = 1.6 nM	TI LI LO TS
CL000025	HEK-293T Cell Line Info	Homo sapiens (Human)	3
1	EC50 = 13.18 nM	TI LI LO TS
2	EC50 = 15.85 nM	TI LI LO TS
3	EC50 = 16218.1 nM	TI LI LO TS
CL000035	NIH 3T3 Cell Line Info	Mus musculus (Mouse)	1
1	EC50 = 2600 nM	TI LI LO TS