Brief Information of the Compound and Protein
Compound Name
(E)-N-[3-[(5-chloro-4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-yl)amino]-4-methoxyphenyl]-4-(dimethylamino)but-2-enamide
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PubChem ID
CID: 73294507
Canonical SMILES
COc1ccc(NC(=O)\C=C\CN(C)C)cc1Nc1ncc(Cl)c(n1)-c1cnn2ccccc12
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Compound Formula C24H24ClN7O2
Compound Structure
Protein Name
Epidermal growth factor receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase EGFR family
Uniprot ID
P00533
Gene Name
EGFR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000323 LoVo Homo sapiens (Human)  2
1
IC50 > 20000 nM
   TI
   LI
   LO
   TS
2
IC50 = 23000 nM
   TI
   LI
   LO
   TS
CL000157 NCI-H1975 Homo sapiens (Human)  2
1
IC50 = 91 nM
   TI
   LI
   LO
   TS
2
IC50 = 96 nM
   TI
   LI
   LO
   TS