Brief Information of the Compound and Protein
Compound Name
N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
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PubChem ID
CID: 5329102
SID: 14830382
Canonical SMILES
CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C
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Compound Formula C22H27FN4O2
Compound Structure
Protein Name
Epidermal growth factor receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase EGFR family
Uniprot ID
P00533
Gene Name
EGFR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000052 A-431 Homo sapiens (Human)  1
1
IC50 = 172.1 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 31.8 nM
2 IC50 = 140 nM
3 IC50 = 18000 nM
4 IC50 > 20000 nM
5 Kd = 860 nM
6 Kd = 2400 nM
7 Kd = 6800 nM
8 Kd > 10000 nM