Brief Information of the Compound and Protein
Compound Name
1-propan-2-yl-1-[[3-(1,3-thiazol-2-yl)phenyl]methyl]-3-[4-(trifluoromethoxy)phenyl]urea
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PubChem ID
CID: 90014603
Canonical SMILES
CC(C)N(Cc1cccc(c1)-c1nccs1)C(=O)Nc1ccc(OC(F)(F)F)cc1
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Compound Formula C21H20F3N3O2S
Compound Structure
Protein Name
High affinity nerve growth factor receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase Trk family
Uniprot ID
P04629
Gene Name
NTRK1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000043 U2OS Homo sapiens (Human)  1
1
IC50 = 56 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 EC50 = 119 nM
2 IC50 = 132 nM
3 Kd = 63 nM