Brief Information of the Compound and Protein
Compound Name
 Compound Info 
Cariprazine
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 PubChem ID
SID: 24759793
Canonical SMILES
CN(C)C(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)c2cccc(Cl)c2Cl)CC1
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Compound Formula C21H32Cl2N4O
Compound Structure
Protein Name
 Protein Info 
D(2) dopamine receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Dopamine receptor
Uniprot ID
P14416
Gene Name
DRD2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  5
1
Ki = 0.41 nM
   TI
   LI
   LO
   TS
2
Ki = 0.47 nM
   TI
   LI
   LO
   TS
3
Ki = 0.49 nM
   TI
   LI
   LO
   TS
4
Ki = 1.3 nM
   TI
   LI
   LO
   TS
5
Ki = 17.78 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  3
1
EC50 = 3.467 nM
   TI
   LI
   LO
   TS
2
Ki = 0.49 nM
   TI
   LI
   LO
   TS
3
Ki = 0.5012 nM
   TI
   LI
   LO
   TS