Brief Information of the Compound and Protein
Compound Name
 Compound Info 
2-fluoro-N-[[5-(6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-imidazol-2-yl]methyl]aniline
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 PubChem ID
CID: 54766013
SID: 131530595
Canonical SMILES
Cc1cccc(n1)-c1[nH]c(CNc2ccccc2F)nc1-c1ccc2ncnn2c1
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Compound Formula C22H18FN7
Compound Structure
Protein Name
 Protein Info 
TGF-beta receptor type-1
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TKL protein kinase group
>
TKL protein kinase STKR family
>
TKL protein kinase STKR Type 1 subfamily
Uniprot ID
P36897
Gene Name
TGFBR1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000150 HaCaT
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 16.5 nM
   TI
   LI
   LO
   TS
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  4
1
IC50 = 7 nM
   TI
   LI
   LO
   TS
2
IC50 = 9.67 nM
   TI
   LI
   LO
   TS
3
IC50 = 10 nM
   TI
   LI
   LO
   TS
4
IC50 = 14 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 13 nM
2 Ki = 6.296 nM
3 Ki = 20.59 nM