Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(4S,5R)-Nutlin-3
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 PubChem ID
CID: 11433190
SID: 16530573
Canonical SMILES
COc1ccc(C2=N[C@H]([C@H](N2C(=O)N2CCNC(=O)C2)c2ccc(Cl)cc2)c2ccc(Cl)cc2)c(OC(C)C)c1
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Compound Formula C30H30Cl2N4O4
Compound Structure
Protein Name
 Protein Info 
E3 ubiquitin-protein ligase Mdm2
Protein Classification
Other nuclear protein
Uniprot ID
Q00987
Gene Name
MDM2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000276 PA-1
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 > 60000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 10 nM
2 IC50 = 61 nM
3 IC50 = 70 nM
4 IC50 = 88 nM
5 IC50 = 90 nM
6 IC50 = 100 nM
7 IC50 = 610 nM
8 IC50 = 13600 nM
9 IC50 = 30000 nM
10 Kd = 35 nM
11 Kd = 700 nM
12 Kd < 1000 nM
13 Ki = 6.4 nM
14 Ki = 36 nM
15 Ki = 90 nM
16 Ki = 110 nM
17 Ki = 121 nM
18 Ki = 140 nM